no code implementations • 29 Feb 2024 • Yunfan Li, Arman Sabbaghi, Jonathan R. Walsh, Charles K. Fisher
We demonstrate that prognostic score adjustment in logistic regression increases the power of the Wald test for the conditional odds ratio under a fixed sample size, or alternatively reduces the necessary sample size to achieve a desired power, compared to the unadjusted analysis.
no code implementations • 27 Oct 2023 • Alyssa M. Vanderbeek, Arman Sabbaghi, Jon R. Walsh, Charles K. Fisher
We propose a new Bayesian prognostic covariate adjustment methodology, referred to as Bayesian PROCOVA, that combines these two strategies.
no code implementations • 25 Sep 2023 • Alyssa M. Vanderbeek, Anna A. Vidovszky, Jessica L. Ross, Arman Sabbaghi, Jonathan R. Walsh, Charles K. Fisher, the Critical Path for Alzheimer's Disease, the Alzheimer's Disease Neuroimaging Initiative, the European Prevention of Alzheimer's Disease, Consortium, the Alzheimer's Disease Cooperative Study
A crucial task for a randomized controlled trial (RCT) is to specify a statistical method that can yield an efficient estimator and powerful test for the treatment effect.
1 code implementation • 15 May 2023 • Alex H. Lang, Anton D. Loukianov, Charles K. Fisher
Conditional generative models are capable of using contextual information as input to create new imaginative outputs.
no code implementations • 3 Nov 2022 • Charles K. Fisher
Restricted Boltzmann Machines (RBMs) are probabilistic generative models that can be trained by maximum likelihood in principle, but are usually trained by an approximate algorithm called Contrastive Divergence (CD) in practice.
no code implementations • 24 Dec 2020 • Daniele Bertolini, Anton D. Loukianov, Aaron M. Smith, David Li-Bland, Yannick Pouliot, Jonathan R. Walsh, Charles K. Fisher
Alzheimer's Disease (AD) is a neurodegenerative disease that affects subjects in a broad range of severity and is assessed in clinical trials with multiple cognitive and functional instruments.
no code implementations • 4 Feb 2020 • Jonathan R. Walsh, Aaron M. Smith, Yannick Pouliot, David Li-Bland, Anton Loukianov, Charles K. Fisher
Multiple Sclerosis (MS) is a neurodegenerative disorder characterized by a complex set of clinical assessments.
no code implementations • 10 Jul 2018 • Charles K. Fisher, Aaron M. Smith, Jonathan R. Walsh, the Coalition Against Major Diseases
Most approaches to machine learning from electronic health data can only predict a single endpoint.
1 code implementation • 23 Apr 2018 • Charles K. Fisher, Aaron M. Smith, Jonathan R. Walsh
Restricted Boltzmann Machines (RBMs) are a class of generative neural network that are typically trained to maximize a log-likelihood objective function.
7 code implementations • 23 Mar 2018 • Pankaj Mehta, Marin Bukov, Ching-Hao Wang, Alexandre G. R. Day, Clint Richardson, Charles K. Fisher, David J. Schwab
The purpose of this review is to provide an introduction to the core concepts and tools of machine learning in a manner easily understood and intuitive to physicists.
no code implementations • 3 Nov 2014 • Charles K. Fisher, Pankaj Mehta
Identifying small subsets of features that are relevant for prediction and/or classification tasks is a central problem in machine learning and statistics.
no code implementations • 24 Sep 2014 • Charles K. Fisher
I propose a variational approach to maximum pseudolikelihood inference of the Ising model.
no code implementations • 30 Jul 2014 • Charles K. Fisher, Pankaj Mehta
Feature selection, identifying a subset of variables that are relevant for predicting a response, is an important and challenging component of many methods in statistics and machine learning.