Search Results for author: Thomas E. Yankeelov

Found 7 papers, 0 papers with code

Forum on immune digital twins: a meeting report

no code implementations26 Oct 2023 Reinhard Laubenbacher, Fred Adler, Gary An, Filippo Castiglione, Stephen Eubank, Luis L. Fonseca, James Glazier, Tomas Helikar, Marti Jett-Tilton, Denise Kirschner, Paul Macklin, Borna Mehrad, Beth Moore, Virginia Pasour, Ilya Shmulevich, Amber Smith, Isabel Voigt, Thomas E. Yankeelov, Tjalf Ziemssen

If medical digital twins are to faithfully capture the characteristics of a patient's immune system, we need to answer many questions, such as: What do we need to know about the immune system to build mathematical models that reflect features of an individual?

Patient-specific, mechanistic models of tumor growth incorporating artificial intelligence and big data

no code implementations28 Aug 2023 Guillermo Lorenzo, Syed Rakin Ahmed, David A. Hormuth II, Brenna Vaughn, Jayashree Kalpathy-Cramer, Luis Solorio, Thomas E. Yankeelov, Hector Gomez

Despite the remarkable advances in cancer diagnosis, treatment, and management that have occurred over the past decade, malignant tumors remain a major public health problem.

Identifying mechanisms driving the early response of triple negative breast cancer patients to neoadjuvant chemotherapy using a mechanistic model integrating in vitro and in vivo imaging data

no code implementations8 Dec 2022 Guillermo Lorenzo, Angela M. Jarrett, Christian T. Meyer, Vito Quaranta, Darren R. Tyson, Thomas E. Yankeelov

As longitudinal \textsl{in vivo} MRI data for model calibration is limited, we perform a sensitivity analysis to identify the model mechanisms driving the response to two NAC drug combinations: doxorubicin with cyclophosphamide, and paclitaxel with carboplatin.

An untrained deep learning method for reconstructing dynamic magnetic resonance images from accelerated model-based data

no code implementations3 May 2022 Kalina P. Slavkova, Julie C. DiCarlo, Viraj Wadhwa, Chengyue Wu, John Virostko, Sidharth Kumar, Thomas E. Yankeelov, Jonathan I. Tamir

We conclude that the use of an untrained neural network together with a physics-based regularization loss shows promise as a measure for determining the optimal stopping point in training without relying on fully-sampled ground truth data.

SSIM

In Vitro Vascularized Tumor Platform for Modeling Tumor-Vasculature Interactions of Inflammatory Breast Cancer

no code implementations17 Sep 2018 Manasa Gadde, Caleb Phillips, Neda Ghousifam, Anna G. Sorace, Enoch Wong, Savitri Krishnamurthy, Anum Syed, Omar Rahal, Thomas E. Yankeelov, Wendy A. Woodward, Marissa Nichole Rylander

In this study, we developed the first three-dimensional, in vitro, vascularized, breast tumor platform to quantify the spatial and temporal dynamics of tumor-vasculature and tumor-ECM interactions specific to IBC.

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