no code implementations • 29 Apr 2024 • Luzhe Huang, Yuzhu Li, Nir Pillar, Tal Keidar Haran, William Dean Wallace, Aydogan Ozcan
Here, we present an autonomous quality and hallucination assessment method (termed AQuA), mainly designed for virtual tissue staining, while also being applicable to histochemical staining.
no code implementations • 1 Apr 2024 • Sahan Yoruc Selcuk, Xilin Yang, Bijie Bai, Yijie Zhang, Yuzhu Li, Musa Aydin, Aras Firat Unal, Aditya Gomatam, Zhen Guo, Darrow Morgan Angus, Goren Kolodney, Karine Atlan, Tal Keidar Haran, Nir Pillar, Aydogan Ozcan
Human epidermal growth factor receptor 2 (HER2) is a critical protein in cancer cell growth that signifies the aggressiveness of breast cancer (BC) and helps predict its prognosis.
no code implementations • 4 Feb 2024 • Guangdong Ma, Xilin Yang, Bijie Bai, Jingxi Li, Yuhang Li, Tianyi Gan, Che-Yung Shen, Yijie Zhang, Yuzhu Li, Mona Jarrahi, Aydogan Ozcan
We demonstrated the feasibility of this reconfigurable multiplexed diffractive design by approximating 256 randomly selected permutation matrices using K=4 rotatable diffractive layers.
no code implementations • 2 Aug 2023 • Yuzhu Li, Nir Pillar, Jingxi Li, Tairan Liu, Di wu, Songyu Sun, Guangdong Ma, Kevin De Haan, Luzhe Huang, Sepehr Hamidi, Anatoly Urisman, Tal Keidar Haran, William Dean Wallace, Jonathan E. Zuckerman, Aydogan Ozcan
Histological examination is a crucial step in an autopsy; however, the traditional histochemical staining of post-mortem samples faces multiple challenges, including the inferior staining quality due to autolysis caused by delayed fixation of cadaver tissue, as well as the resource-intensive nature of chemical staining procedures covering large tissue areas, which demand substantial labor, cost, and time.
no code implementations • 13 Nov 2022 • Bijie Bai, Xilin Yang, Yuzhu Li, Yijie Zhang, Nir Pillar, Aydogan Ozcan
Histological staining is the gold standard for tissue examination in clinical pathology and life-science research, which visualizes the tissue and cellular structures using chromatic dyes or fluorescence labels to aid the microscopic assessment of tissue.
no code implementations • 17 Sep 2022 • Shuyang Shi, Yuzhu Li, Wei Dong
Then, adaptive estimation laws for mass-inertia parameters are designed based on a filter operation.
no code implementations • 14 Jul 2022 • Xilin Yang, Bijie Bai, Yijie Zhang, Yuzhu Li, Kevin De Haan, Tairan Liu, Aydogan Ozcan
Unlike a single neural network structure which only takes one stain type as input to digitally output images of another stain type, C-DNN first uses virtual staining to transform autofluorescence microscopy images into H&E and then performs stain transfer from H&E to the domain of the other stain in a cascaded manner.
no code implementations • 6 Jul 2022 • Yijie Zhang, Luzhe Huang, Tairan Liu, Keyi Cheng, Kevin De Haan, Yuzhu Li, Bijie Bai, Aydogan Ozcan
Here, we introduce a fast virtual staining framework that can stain defocused autofluorescence images of unlabeled tissue, achieving equivalent performance to virtual staining of in-focus label-free images, also saving significant imaging time by lowering the microscope's autofocusing precision.
no code implementations • 30 Jun 2022 • Tairan Liu, Yuzhu Li, Hatice Ceylan Koydemir, Yijie Zhang, Ethan Yang, Merve Eryilmaz, Hongda Wang, Jingxi Li, Bijie Bai, Guangdong Ma, Aydogan Ozcan
We also demonstrated that this data-driven plaque assay offers the capability of quantifying the infected area of the cell monolayer, performing automated counting and quantification of PFUs and virus-infected areas over a 10-fold larger dynamic range of virus concentration than standard viral plaque assays.
no code implementations • 7 May 2022 • Yuzhu Li, Tairan Liu, Hatice Ceylan Koydemir, Hongda Wang, Keelan O'Riordan, Bijie Bai, Yuta Haga, Junji Kobashi, Hitoshi Tanaka, Takaya Tamaru, Kazunori Yamaguchi, Aydogan Ozcan
Due to the large scalability, ultra-large field-of-view, and low cost of the TFT-based image sensors, this platform can be integrated with each agar plate to be tested and disposed of after the automated CFU count.
no code implementations • 8 Dec 2021 • Bijie Bai, Hongda Wang, Yuzhu Li, Kevin De Haan, Francesco Colonnese, Yujie Wan, Jingyi Zuo, Ngan B. Doan, Xiaoran Zhang, Yijie Zhang, Jingxi Li, Wenjie Dong, Morgan Angus Darrow, Elham Kamangar, Han Sung Lee, Yair Rivenson, Aydogan Ozcan
The immunohistochemical (IHC) staining of the human epidermal growth factor receptor 2 (HER2) biomarker is widely practiced in breast tissue analysis, preclinical studies and diagnostic decisions, guiding cancer treatment and investigation of pathogenesis.