no code implementations • 3 Oct 2023 • Xianjing Liu, Bo Li, Meike W. Vernooij, Eppo B. Wolvius, Gennady V. Roshchupkin, Esther E. Bron
AI has greatly enhanced medical image analysis, yet its use in epidemiological population imaging studies remains limited due to visualization challenges in non-linear models and lack of confounder control.
no code implementations • 15 Aug 2023 • Wenjie Kang, Bo Li, Janne M. Papma, Lize C. Jiskoot, Peter Paul De Deyn, Geert Jan Biessels, Jurgen A. H. R. Claassen, Huub A. M. Middelkoop, Wiesje M. van der Flier, Inez H. G. B. Ramakers, Stefan Klein, Esther E. Bron
However, some machine learning methods based on imaging data have poor interpretability because it is usually unclear how they make their decisions.
no code implementations • 15 Aug 2022 • Carole H. Sudre, Kimberlin Van Wijnen, Florian Dubost, Hieab Adams, David Atkinson, Frederik Barkhof, Mahlet A. Birhanu, Esther E. Bron, Robin Camarasa, Nish Chaturvedi, Yuan Chen, Zihao Chen, Shuai Chen, Qi Dou, Tavia Evans, Ivan Ezhov, Haojun Gao, Marta Girones Sanguesa, Juan Domingo Gispert, Beatriz Gomez Anson, Alun D. Hughes, M. Arfan Ikram, Silvia Ingala, H. Rolf Jaeger, Florian Kofler, Hugo J. Kuijf, Denis Kutnar, Minho Lee, Bo Li, Luigi Lorenzini, Bjoern Menze, Jose Luis Molinuevo, Yiwei Pan, Elodie Puybareau, Rafael Rehwald, Ruisheng Su, Pengcheng Shi, Lorna Smith, Therese Tillin, Guillaume Tochon, Helene Urien, Bas H. M. van der Velden, Isabelle F. van der Velpen, Benedikt Wiestler, Frank J. Wolters, Pinar Yilmaz, Marius de Groot, Meike W. Vernooij, Marleen de Bruijne
This challenge aimed to promote the development of methods for automated detection and segmentation of small and sparse imaging markers of cerebral small vessel disease, namely enlarged perivascular spaces (EPVS) (Task 1), cerebral microbleeds (Task 2) and lacunes of presumed vascular origin (Task 3) while leveraging weak and noisy labels.
no code implementations • 29 Jun 2022 • Vikram Venkatraghavan, Sebastian R. van der Voort, Daniel Bos, Marion Smits, Frederik Barkhof, Wiro J. Niessen, Stefan Klein, Esther E. Bron
Regarding prediction, i. e. estimation of the future 'condition' of the patient, we will zoom in on use cases such as predicting the disease course in multiple sclerosis and predicting patient outcomes after treatment in brain cancer.
no code implementations • 15 Dec 2021 • Esther E. Bron, Stefan Klein, Annika Reinke, Janne M. Papma, Lena Maier-Hein, Daniel C. Alexander, Neil P. Oxtoby
Key for increasing impact in this way are larger testing data sizes, which could be reached by sharing algorithms rather than data to exploit data that cannot be shared.
2 code implementations • 19 Aug 2021 • Martijn P. A. Starmans, Sebastian R. van der Voort, Thomas Phil, Milea J. M. Timbergen, Melissa Vos, Guillaume A. Padmos, Wouter Kessels, David Hanff, Dirk J. Grunhagen, Cornelis Verhoef, Stefan Sleijfer, Martin J. van den Bent, Marion Smits, Roy S. Dwarkasing, Christopher J. Els, Federico Fiduzi, Geert J. L. H. van Leenders, Anela Blazevic, Johannes Hofland, Tessa Brabander, Renza A. H. van Gils, Gaston J. H. Franssen, Richard A. Feelders, Wouter W. de Herder, Florian E. Buisman, Francois E. J. A. Willemssen, Bas Groot Koerkamp, Lindsay Angus, Astrid A. M. van der Veldt, Ana Rajicic, Arlette E. Odink, Mitchell Deen, Jose M. Castillo T., Jifke Veenland, Ivo Schoots, Michel Renckens, Michail Doukas, Rob A. de Man, Jan N. M. IJzermans, Razvan L. Miclea, Peter B. Vermeulen, Esther E. Bron, Maarten G. Thomeer, Jacob J. Visser, Wiro J. Niessen, Stefan Klein
In this study we propose a framework for automatically optimizing the construction of radiomics workflows per application.
1 code implementation • 28 Dec 2020 • Bo Li, Wiro J. Niessen, Stefan Klein, Marius de Groot, M. Arfan Ikram, Meike W. Vernooij, Esther E. Bron
This work presents a single-step deep-learning framework for longitudinal image analysis, coined Segis-Net.
no code implementations • 16 Dec 2020 • Esther E. Bron, Stefan Klein, Janne M. Papma, Lize C. Jiskoot, Vikram Venkatraghavan, Jara Linders, Pauline Aalten, Peter Paul De Deyn, Geert Jan Biessels, Jurgen A. H. R. Claassen, Huub A. M. Middelkoop, Marion Smits, Wiro J. Niessen, John C. van Swieten, Wiesje M. van der Flier, Inez H. G. B. Ramakers, Aad van der Lugt
For prediction in MCI, performances decreased for both SVM (0. 665) and CNN (0. 702).
no code implementations • 3 Nov 2020 • Bo Li, Wiro J. Niessen, Stefan Klein, M. Arfan Ikram, Meike W. Vernooij, Esther E. Bron
We here propose an analytical framework based on an unbiased learning strategy for group-wise registration that simultaneously registers images to the mean space of a group to obtain consistent segmentations.
no code implementations • 15 Sep 2020 • Vikram Venkatraghavan, Stefan Klein, Lana Fani, Leontine S. Ham, Henri Vrooman, M. Kamran Ikram, Wiro J. Niessen, Esther E. Bron
In this work, we determined the effect of APOE alleles on the disease progression timeline of AD using a discriminative event-based model (DEBM).
no code implementations • 26 May 2020 • Bo Li, Marius de Groot, Rebecca M. E. Steketee, Rozanna Meijboom, Marion Smits, Meike W. Vernooij, M. Arfan Ikram, Jiren Liu, Wiro J. Niessen, Esther E. Bron
This 3D end-to-end method is trained to segment 25 WM tracts in aging individuals from a large population-based study (N=9752, 1. 5T MRI).
4 code implementations • 9 Feb 2020 • Razvan V. Marinescu, Neil P. Oxtoby, Alexandra L. Young, Esther E. Bron, Arthur W. Toga, Michael W. Weiner, Frederik Barkhof, Nick C. Fox, Arman Eshaghi, Tina Toni, Marcin Salaterski, Veronika Lunina, Manon Ansart, Stanley Durrleman, Pascal Lu, Samuel Iddi, Dan Li, Wesley K. Thompson, Michael C. Donohue, Aviv Nahon, Yarden Levy, Dan Halbersberg, Mariya Cohen, Huiling Liao, Tengfei Li, Kaixian Yu, Hongtu Zhu, Jose G. Tamez-Pena, Aya Ismail, Timothy Wood, Hector Corrada Bravo, Minh Nguyen, Nanbo Sun, Jiashi Feng, B. T. Thomas Yeo, Gang Chen, Ke Qi, Shiyang Chen, Deqiang Qiu, Ionut Buciuman, Alex Kelner, Raluca Pop, Denisa Rimocea, Mostafa M. Ghazi, Mads Nielsen, Sebastien Ourselin, Lauge Sorensen, Vikram Venkatraghavan, Keli Liu, Christina Rabe, Paul Manser, Steven M. Hill, James Howlett, Zhiyue Huang, Steven Kiddle, Sach Mukherjee, Anais Rouanet, Bernd Taschler, Brian D. M. Tom, Simon R. White, Noel Faux, Suman Sedai, Javier de Velasco Oriol, Edgar E. V. Clemente, Karol Estrada, Leon Aksman, Andre Altmann, Cynthia M. Stonnington, Yalin Wang, Jianfeng Wu, Vivek Devadas, Clementine Fourrier, Lars Lau Raket, Aristeidis Sotiras, Guray Erus, Jimit Doshi, Christos Davatzikos, Jacob Vogel, Andrew Doyle, Angela Tam, Alex Diaz-Papkovich, Emmanuel Jammeh, Igor Koval, Paul Moore, Terry J. Lyons, John Gallacher, Jussi Tohka, Robert Ciszek, Bruno Jedynak, Kruti Pandya, Murat Bilgel, William Engels, Joseph Cole, Polina Golland, Stefan Klein, Daniel C. Alexander
TADPOLE's unique results suggest that current prediction algorithms provide sufficient accuracy to exploit biomarkers related to clinical diagnosis and ventricle volume, for cohort refinement in clinical trials for Alzheimer's disease.
no code implementations • 8 Mar 2019 • Vikram Venkatraghavan, Florian Dubost, Esther E. Bron, Wiro J. Niessen, Marleen de Bruijne, Stefan Klein
In order to validate the biomarker ordering obtained using nDEBM, we also present a framework for Simulation of Imaging Biomarkers' Temporal Evolution (SImBioTE) that mimics neurodegeneration in brain regions.
1 code implementation • 10 Aug 2018 • Vikram Venkatraghavan, Esther E. Bron, Wiro J. Niessen, Stefan Klein, for the Alzheimer's Disease Neuroimaging Initiative
We evaluated the proposed method on Alzheimer's Disease Neuroimaging Initiative (ADNI) data and compared the results with existing state-of-the-art EBM methods.