no code implementations • 6 Mar 2024 • Karina Silina, Francesco Ciompi
Quantification of lymphoid aggregates including tertiary lymphoid structures with germinal centers in histology images of cancer is a promising approach for developing prognostic and predictive tissue biomarkers.
no code implementations • 16 Feb 2024 • Nadieh Khalili, Joey Spronck, Francesco Ciompi, Jeroen van der Laak, Geert Litjens
Deep learning algorithms, often critiqued for their 'black box' nature, traditionally fall short in providing the necessary transparency for trusted clinical use.
1 code implementation • 21 Nov 2023 • Cristian Tommasino, Cristiano Russo, Antonio Maria Rinaldi, Francesco Ciompi
We present HoVer-UNet, an approach to distill the knowledge of the multi-branch HoVerNet framework for nuclei instance segmentation and classification in histopathology.
no code implementations • 16 Jan 2023 • Yiping Jiao, Jeroen van der Laak, Shadi Albarqouni, Zhang Li, Tao Tan, Abhir Bhalerao, Jiabo Ma, Jiamei Sun, Johnathan Pocock, Josien P. W. Pluim, Navid Alemi Koohbanani, Raja Muhammad Saad Bashir, Shan E Ahmed Raza, Sibo Liu, Simon Graham, Suzanne Wetstein, Syed Ali Khurram, Thomas Watson, Nasir Rajpoot, Mitko Veta, Francesco Ciompi
Additionally, we present post-competition results where we show how the presented methods perform on an independent set of lung cancer slides, which was not part of the initial competition, as well as a comparison on lymphocyte assessment between presented methods and a panel of pathologists.
1 code implementation • 14 Nov 2022 • Eduard Chelebian, Francesco Ciompi, Carolina Wählby
Annotations are necessary to develop computer vision algorithms for histopathology, but dense annotations at a high resolution are often time-consuming to make.
no code implementations • 6 Apr 2022 • Marc Aubreville, Nikolas Stathonikos, Christof A. Bertram, Robert Klopleisch, Natalie ter Hoeve, Francesco Ciompi, Frauke Wilm, Christian Marzahl, Taryn A. Donovan, Andreas Maier, Jack Breen, Nishant Ravikumar, Youjin Chung, Jinah Park, Ramin Nateghi, Fattaneh Pourakpour, Rutger H. J. Fick, Saima Ben Hadj, Mostafa Jahanifar, Nasir Rajpoot, Jakob Dexl, Thomas Wittenberg, Satoshi Kondo, Maxime W. Lafarge, Viktor H. Koelzer, Jingtang Liang, YuBo Wang, Xi Long, Jingxin Liu, Salar Razavi, April Khademi, Sen yang, Xiyue Wang, Mitko Veta, Katharina Breininger
The goal of the MICCAI MIDOG 2021 challenge has been to propose and evaluate methods that counter this domain shift and derive scanner-agnostic mitosis detection algorithms.
no code implementations • 16 Sep 2021 • John-Melle Bokhorsta, Iris D. Nagtegaal, Filippo Fraggetta, Simona Vatrano, Wilma Mesker, Michael Vieth, Jeroen van der Laak, Francesco Ciompi
Artificial Intelligence (AI) can potentially support histopathologists in the diagnosis of a broad spectrum of cancer types.
no code implementations • MICCAI Workshop COMPAY 2021 • Niccolò Marini, Sebastian Otálora, Francesco Ciompi, Gianmaria Silvello, Stefano Marchesin, Simona Vatrano, Gianziana Buttafuoco, Manfredo Atzori, Henning Müller
Global annotations refer to global findings in the high-resolution image and do not include information about the location of the regions of interest or the magnification levels used to identify a finding.
2 code implementations • 30 Mar 2021 • Marc Aubreville, Christof Bertram, Mitko Veta, Robert Klopfleisch, Nikolas Stathonikos, Katharina Breininger, Natalie ter Hoeve, Francesco Ciompi, Andreas Maier
Hypothesizing that the scanner device plays a decisive role in this effect, we evaluated the susceptibility of a standard mitosis detection approach to the domain shift introduced by using a different whole slide scanner.
no code implementations • 9 Dec 2020 • Caner Mercan, Maschenka Balkenhol, Roberto Salgado, Mark Sherman, Philippe Vielh, Willem Vreuls, Antonio Polonia, Hugo M. Horlings, Wilko Weichert, Jodi M. Carter, Peter Bult, Matthias Christgen, Carsten Denkert, Koen van de Vijver, Jeroen van der Laak, Francesco Ciompi
Nuclear pleomorphism, defined herein as the extent of abnormalities in the overall appearance of tumor nuclei, is one of the components of the three-tiered breast cancer grading.
1 code implementation • 22 Jun 2020 • Mart van Rijthoven, Maschenka Balkenhol, Karina Siliņa, Jeroen van der Laak, Francesco Ciompi
We propose HookNet, a semantic segmentation model for histopathology whole-slide images, which combines context and details via multiple branches of encoder-decoder convolutional neural networks.
no code implementations • MIDL 2019 • David Tellez, Diederik Hoppener, Cornelis Verhoef, Dirk Grunhagen, Pieter Nierop, Michal Drozdzal, Jeroen van der Laak, Francesco Ciompi
Additionally, we trained multiple encoders with different training objectives, e. g. unsupervised and variants of MTL, and observed a positive correlation between the number of tasks in MTL and the system performance on the TUPAC16 dataset.
no code implementations • 17 Mar 2020 • Caner Mercan, Germonda Reijnen-Mooij, David Tellez Martin, Johannes Lotz, Nick Weiss, Marcel van Gerven, Francesco Ciompi
We propose a virtual staining methodology based on Generative Adversarial Networks to map histopathology images of breast cancer tissue from H&E stain to PHH3 and vice versa.
1 code implementation • 16 Aug 2019 • Nick Pawlowski, Suvrat Bhooshan, Nicolas Ballas, Francesco Ciompi, Ben Glocker, Michal Drozdzal
In some important computer vision domains, such as medical or hyperspectral imaging, we care about the classification of tiny objects in large images.
no code implementations • 18 Feb 2019 • David Tellez, Geert Litjens, Peter Bandi, Wouter Bulten, John-Melle Bokhorst, Francesco Ciompi, Jeroen van der Laak
Stain variation is a phenomenon observed when distinct pathology laboratories stain tissue slides that exhibit similar but not identical color appearance.
1 code implementation • 7 Nov 2018 • David Tellez, Geert Litjens, Jeroen van der Laak, Francesco Ciompi
Second, a convolutional neural network (CNN) is trained on these compressed image representations to predict image-level labels, avoiding the need for fine-grained manual annotations.
no code implementations • 17 Aug 2018 • David Tellez, Maschenka Balkenhol, Irene Otte-Holler, Rob van de Loo, Rob Vogels, Peter Bult, Carla Wauters, Willem Vreuls, Suzanne Mol, Nico Karssemeijer, Geert Litjens, Jeroen van der Laak, Francesco Ciompi
Application of CNNs to hematoxylin and eosin (H&E) stained histological tissue sections is hampered by: (1) noisy and expensive reference standards established by pathologists, (2) lack of generalization due to staining variation across laboratories, and (3) high computational requirements needed to process gigapixel whole-slide images (WSIs).
no code implementations • 22 Jul 2018 • Mitko Veta, Yujing J. Heng, Nikolas Stathonikos, Babak Ehteshami Bejnordi, Francisco Beca, Thomas Wollmann, Karl Rohr, Manan A. Shah, Dayong Wang, Mikael Rousson, Martin Hedlund, David Tellez, Francesco Ciompi, Erwan Zerhouni, David Lanyi, Matheus Viana, Vassili Kovalev, Vitali Liauchuk, Hady Ahmady Phoulady, Talha Qaiser, Simon Graham, Nasir Rajpoot, Erik Sjöblom, Jesper Molin, Kyunghyun Paeng, Sangheum Hwang, Sunggyun Park, Zhipeng Jia, Eric I-Chao Chang, Yan Xu, Andrew H. Beck, Paul J. van Diest, Josien P. W. Pluim
The best performing automatic method for the first task achieved a quadratic-weighted Cohen's kappa score of $\kappa$ = 0. 567, 95% CI [0. 464, 0. 671] between the predicted scores and the ground truth.
no code implementations • 17 Mar 2017 • Péter Bándi, Rob van de Loo, Milad Intezar, Daan Geijs, Francesco Ciompi, Bram van Ginneken, Jeroen van der Laak, Geert Litjens
Tissue segmentation is an important pre-requisite for efficient and accurate diagnostics in digital pathology.
1 code implementation • 20 Feb 2017 • Francesco Ciompi, Oscar Geessink, Babak Ehteshami Bejnordi, Gabriel Silva de Souza, Alexi Baidoshvili, Geert Litjens, Bram van Ginneken, Iris Nagtegaal, Jeroen van der Laak
The development of reliable imaging biomarkers for the analysis of colorectal cancer (CRC) in hematoxylin and eosin (H&E) stained histopathology images requires an accurate and reproducible classification of the main tissue components in the image.
no code implementations • 19 Feb 2017 • Geert Litjens, Thijs Kooi, Babak Ehteshami Bejnordi, Arnaud Arindra Adiyoso Setio, Francesco Ciompi, Mohsen Ghafoorian, Jeroen A. W. M. van der Laak, Bram van Ginneken, Clara I. Sánchez
Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images.
no code implementations • 28 Oct 2016 • Francesco Ciompi, Kaman Chung, Sarah J. van Riel, Arnaud Arindra Adiyoso Setio, Paul K. Gerke, Colin Jacobs, Ernst Th. Scholten, Cornelia Schaefer-Prokop, Mathilde M. W. Wille, Alfonso Marchiano, Ugo Pastorino, Mathias Prokop, Bram van Ginneken
The introduction of lung cancer screening programs will produce an unprecedented amount of chest CT scans in the near future, which radiologists will have to read in order to decide on a patient follow-up strategy.